A first line of defense against pathogens, innate immunity is essential for life. Errors in controlling innate immunity can lead to disease: Inflammation caused by the aberrant activity of innate immune receptors is now being viewed as a major driver of several human diseases as well as natural aging. The NOMIS research project Exploring Innate Immune (In)activities aims to systemically study molecular checkpoints that control innate immune function.
Andrea Ablasser and her lab seek to identify allosteric sequence motifs within immune receptors and signaling proteins that limit overall activity and control the strength, duration and resolution of immune responses. The project aims to generate insights into the rules that govern the functioning of innate immunity and to establish the landscape of the regulatory, evolutionary and therapeutic potential of immune signaling pathways.
Wednesday, October 16, 2024 | 18:00 | Kunsthaus Zurich, Chipperfield Building
